9/24/2023 0 Comments Viscosity blood test waldenstrom![]() Treatment options include observation (for asymptomatic patients), plasmapheresis, chemotherapy, and targeted therapies (e.g., rituximab and ibrutinib). Goals of treatment are to reduce symptoms, improve quality of life, and prolong survival. WM is incurable but median overall survival is long (approximately 8 years based on US data). Lymphadenopathy, splenomegaly, and hyperviscosity (which can lead to skin and mucosal bleeding, thrombosis, retinopathy with visual disturbances, and neurological symptoms such as headache, dizziness, and vertigo) are uncommon, but they are important clinical manifestations that require urgent treatment. The pathophysiological hallmark is monoclonal immunoglobulin M (IgM) production by a malignant lymphoplasmacytic clone that resides in the bone marrow.ĭiagnosis is most often made following an incidental finding of an IgM paraprotein on a blood test.Īnaemia (due to marrow infiltration), fatigue, and anorexia are the most common clinical features. Waldenström's macroglobulinaemia (WM) is a rare indolent B-cell lymphoma that most commonly occurs in older white men. ![]()
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